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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1997 1
1998 3
1999 3
2000 3
2001 3
2002 3
2003 5
2004 11
2005 4
2006 2
2007 2
2008 5
2009 11
2010 13
2011 6
2012 5
2013 5
2014 2
2015 6
2016 4
2017 6
2018 3
2019 3
2020 7
2021 3
2022 1
2023 1
2024 0

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113 results

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Page 1
Association analyses of more than 140,000 men identify 63 new prostate cancer susceptibility loci.
Schumacher FR, Al Olama AA, Berndt SI, Benlloch S, Ahmed M, Saunders EJ, Dadaev T, Leongamornlert D, Anokian E, Cieza-Borrella C, Goh C, Brook MN, Sheng X, Fachal L, Dennis J, Tyrer J, Muir K, Lophatananon A, Stevens VL, Gapstur SM, Carter BD, Tangen CM, Goodman PJ, Thompson IM Jr, Batra J, Chambers S, Moya L, Clements J, Horvath L, Tilley W, Risbridger GP, Gronberg H, Aly M, Nordström T, Pharoah P, Pashayan N, Schleutker J, Tammela TLJ, Sipeky C, Auvinen A, Albanes D, Weinstein S, Wolk A, Håkansson N, West CML, Dunning AM, Burnet N, Mucci LA, Giovannucci E, Andriole GL, Cussenot O, Cancel-Tassin G, Koutros S, Beane Freeman LE, Sorensen KD, Orntoft TF, Borre M, Maehle L, Grindedal EM, Neal DE, Donovan JL, Hamdy FC, Martin RM, Travis RC, Key TJ, Hamilton RJ, Fleshner NE, Finelli A, Ingles SA, Stern MC, Rosenstein BS, Kerns SL, Ostrer H, Lu YJ, Zhang HW, Feng N, Mao X, Guo X, Wang G, Sun Z, Giles GG, Southey MC, MacInnis RJ, FitzGerald LM, Kibel AS, Drake BF, Vega A, Gómez-Caamaño A, Szulkin R, Eklund M, Kogevinas M, Llorca J, Castaño-Vinyals G, Penney KL, Stampfer M, Park JY, Sellers TA, Lin HY, Stanford JL, Cybulski C, Wokolorczyk D, Lubinski J, Ostrander EA, Geybels MS, Nordestga… See abstract for full author list ➔ Schumacher FR, et al. Nat Genet. 2018 Jul;50(7):928-936. doi: 10.1038/s41588-018-0142-8. Epub 2018 Jun 11. Nat Genet. 2018. PMID: 29892016 Free PMC article.
Our findings include missense variants rs1800057 (odds ratio (OR) = 1.16; P = 8.2 10(-9); G>C, p.Pro1054Arg) in ATM and rs2066827 (OR = 1.06; P = 2.3 10(-9); T>G, p.Val109Gly) in CDKN1B. The combination of all loci captured 28.4% of the PrCa familial relative risk, a …
Our findings include missense variants rs1800057 (odds ratio (OR) = 1.16; P = 8.2 10(-9); G>C, p.Pro1054Arg) in ATM and rs2066827 (OR = 1 …
CDKN1B mutation and copy number variation are associated with tumor aggressiveness in luminal breast cancer.
Viotto D, Russo F, Anania I, Segatto I, Rampioni Vinciguerra GL, Dall'Acqua A, Bomben R, Perin T, Cusan M, Schiappacassi M, Gerratana L, D'Andrea S, Citron F, Vit F, Musco L, Mattevi MC, Mungo G, Nicoloso MS, Sonego M, Massarut S, Sorio R, Barzan L, Franchin G, Giorda G, Lucia E, Sulfaro S, Giacomarra V, Polesel J, Toffolutti F, Canzonieri V, Puglisi F, Gattei V, Vecchione A, Belletti B, Baldassarre G. Viotto D, et al. J Pathol. 2021 Feb;253(2):234-245. doi: 10.1002/path.5584. Epub 2020 Dec 4. J Pathol. 2021. PMID: 33140857 Free PMC article.
The CDKN1B gene, encoding for the CDK inhibitor p27(kip1) , is mutated in defined human cancer subtypes, including breast, prostate carcinomas and small intestine neuroendocrine tumors. ...Intriguingly, an enrichment for CDKN1B alterations was found in samples from …
The CDKN1B gene, encoding for the CDK inhibitor p27(kip1) , is mutated in defined human cancer subtypes, including breast, prostate c …
CDKN1A and CDKN1B polymorphisms and risk of advanced prostate carcinoma.
Kibel AS, Suarez BK, Belani J, Oh J, Webster R, Brophy-Ebbers M, Guo C, Catalona WJ, Picus J, Goodfellow PJ. Kibel AS, et al. Cancer Res. 2003 May 1;63(9):2033-6. Cancer Res. 2003. PMID: 12727815
The CDKN1B genotype VV was also associated with an increased risk of advanced prostate carcinoma (OR, 1.95; 95% CI, 1.09-3.47). These associations were particularly strong in those patients with androgen-independent disease [OR = 2.88 (95% CI, 1.19-6.97) and 2.11 (95% CI, …
The CDKN1B genotype VV was also associated with an increased risk of advanced prostate carcinoma (OR, 1.95; 95% CI, 1.09-3.47). These …
Interaction effect of PTEN and CDKN1B chromosomal regions on prostate cancer linkage.
Xu J, Langefeld CD, Zheng SL, Gillanders EM, Chang BL, Isaacs SD, Williams AH, Wiley KE, Dimitrov L, Meyers DA, Walsh PC, Trent JM, Isaacs WB. Xu J, et al. Hum Genet. 2004 Aug;115(3):255-62. doi: 10.1007/s00439-004-1144-4. Epub 2004 Jun 5. Hum Genet. 2004. PMID: 15185141
The tumor suppressor functions of PTEN and CDKN1B have been extensively characterized. Recent data from mouse models suggest that, for some organs, the combined action of both PTEN and CDKN1B has a stronger tumor suppressor function than each alone; for the prostate …
The tumor suppressor functions of PTEN and CDKN1B have been extensively characterized. Recent data from mouse models suggest that, fo …
Prevalent mutations in prostate cancer.
Dong JT. Dong JT. J Cell Biochem. 2006 Feb 15;97(3):433-47. doi: 10.1002/jcb.20696. J Cell Biochem. 2006. PMID: 16267836 Review.
These include the ELAC2 (HPC2), MSR1, and RNASEL (HPC1) genes that have germline mutations in familial prostate cancer; AR, ATBF1, EPHB2 (ERK), KLF6, mitochondria DNA, p53, PTEN, and RAS that have somatic mutations in sporadic prostate cancer; AR, BRCA1, BRCA2, CHEK2 (RAD53), CYP …
These include the ELAC2 (HPC2), MSR1, and RNASEL (HPC1) genes that have germline mutations in familial prostate cancer; AR, ATBF1, EPHB2 (ER …
ETV4 promotes late development of prostatic intraepithelial neoplasia and cell proliferation through direct and p53-mediated downregulation of p21.
Cosi I, Pellecchia A, De Lorenzo E, Torre E, Sica M, Nesi G, Notaro R, De Angioletti M. Cosi I, et al. J Hematol Oncol. 2020 Aug 13;13(1):112. doi: 10.1186/s13045-020-00943-w. J Hematol Oncol. 2020. PMID: 32791988 Free PMC article.
RESULTS: ETV4 mice, from two independent transgenic lines, have increased cell proliferation in their prostate and two-thirds of them, by the age of 10 months, developed mouse prostatic intraepithelial neoplasia (mPIN). In these mice, cdkn1a and its p21 protein product wer …
RESULTS: ETV4 mice, from two independent transgenic lines, have increased cell proliferation in their prostate and two-thirds of them, by th …
Distinct altered patterns of p27KIP1 gene expression in benign prostatic hyperplasia and prostatic carcinoma.
Cordon-Cardo C, Koff A, Drobnjak M, Capodieci P, Osman I, Millard SS, Gaudin PB, Fazzari M, Zhang ZF, Massague J, Scher HI. Cordon-Cardo C, et al. J Natl Cancer Inst. 1998 Sep 2;90(17):1284-91. doi: 10.1093/jnci/90.17.1284. J Natl Cancer Inst. 1998. PMID: 9731735
This study was undertaken to identify and to assess potential alterations of p27KIP1 gene expression in patients with benign prostatic hyperplasia (BPH) and patients with prostate cancer. METHODS: We analyzed 130 prostate carcinomas from primary and metastatic sites, as we …
This study was undertaken to identify and to assess potential alterations of p27KIP1 gene expression in patients with benign prostatic …
Stem cell features of benign and malignant prostate epithelial cells.
De Marzo AM, Nelson WG, Meeker AK, Coffey DS. De Marzo AM, et al. J Urol. 1998 Dec;160(6 Pt 2):2381-92. doi: 10.1097/00005392-199812020-00004. J Urol. 1998. PMID: 9817389 Free article. Review.
PURPOSE: We present a new hypothesis suggesting that the different malignant potential of benign prostatic hyperplasia (BPH) and high grade prostatic intraepithelial neoplasia may be explained by distinct alterations in stem cell-like properties. ...In high grade …
PURPOSE: We present a new hypothesis suggesting that the different malignant potential of benign prostatic hyperplasia (BPH) and high …
Id1 and Id3 expression is associated with increasing grade of prostate cancer: Id3 preferentially regulates CDKN1B.
Sharma P, Patel D, Chaudhary J. Sharma P, et al. Cancer Med. 2012 Oct;1(2):187-97. doi: 10.1002/cam4.19. Epub 2012 Aug 28. Cancer Med. 2012. PMID: 23342268 Free PMC article.
Moreover, through gene silencing approaches we show that Id1 and Id3 primarily attenuates CDKN1A (p21) and CDKN1B (p27), respectively. We also demonstrate that silencing Id3 alone significantly attenuates proliferation of PCa cells as compared with Id1. ...
Moreover, through gene silencing approaches we show that Id1 and Id3 primarily attenuates CDKN1A (p21) and CDKN1B (p27), respectively …
CDKN1B Val 109 Gly variant is not related to risk of prostate cancer.
Zhu L, Wang J, Yue C, Yuan W, Zhang W, Shi L, Mi Y, Wu X, Zhang LF, Zuo L. Zhu L, et al. J Cell Biochem. 2019 Oct;120(10):18346-18356. doi: 10.1002/jcb.29144. Epub 2019 Jun 30. J Cell Biochem. 2019. PMID: 31257659
We adopted odds ratios (ORs) and 95% confidence intervals (CIs) to assess the correlation between CDKN1B Val 109 Gly variant and PCa susceptibility. Moreover, we used in-silico tools to evaluate the relationship of CDKN1B expression and overall survival (OS) or dise …
We adopted odds ratios (ORs) and 95% confidence intervals (CIs) to assess the correlation between CDKN1B Val 109 Gly variant and PCa …
113 results